The Dodge Ram 3500 heavy-duty pickup is available in three cab styles: regular, Quad Cab (crew cab) and Mega Cab (a jumbo crew cab). The regular cabs come with a long bed only, while the Quad Cab has either a short or long cargo bed. The Mega Cab rides on the same wheelbase as the Quad Cab long bed but pairs an even bigger cabin with the short bed. The regular cab comes in ST or SLT trims; the Quad Cab in ST, SLT or Laramie trims; and the Mega Cab is SXT or Laramie only. With the exception of Quad Cab short beds, all Ram 3500s have a dual-rear-wheel axle.

The Ram ST offers 17-inch wheels, vinyl upholstery, 40/20/40-split front bench seat, air-conditioning and a CD player. The SLT adds alloy wheels, cruise control, cloth upholstery, carpet, power accessories and keyless entry. The SXT is equipped similarly, but comes only with the Mega Cab. The luxurious Laramie comes with standard upgrades like dual-zone automatic climate control, leather seating, a power driver seat, upgraded speakers and steering-wheel-mounted audio controls. Options on the upper trims include niceties like a sunroof, power-adjustable pedals, front bucket seats, Bluetooth, navigation system, satellite radio, an upgraded stereo and a rear-seat DVD entertainment system.